Update on the glomerular filtration barrier
نویسندگان
چکیده
منابع مشابه
The Glomerular Filtration Barrier: Components and Crosstalk
The glomerular filtration barrier is a highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules. Its integrity is maintained by physicochemical and signalling interplay among its three core constituents-the glomerular endothelial cell, the basement membrane and visceral epithelial...
متن کاملImpairment in glomerular filtration rate or glomerular filtration barrier and occurrence of stroke.
BACKGROUND Chronic kidney disease (CKD) is associated with substantial burden and is a strong risk factor for cardiovascular disease. However, data on the relationship between CKD and stroke are few and are limited by unreliable or inadequate assessment of renal function. OBJECTIVE To properly assess the relationship between renal insufficiency and stroke in stroke survivors in the United Sta...
متن کاملPodocyte endocytosis in the regulation of the glomerular filtration barrier.
Severe defects in the glomerular filtration barrier result in nephrotic syndrome, which is characterized by massive proteinuria. The podocyte, a specialized epithelial cell with interdigitating foot processes separated by a slit diaphragm, plays a vital role in regulating the passage of proteins from the capillary lumen to Bowman's space. Recent findings suggest a critical role for endocytosis ...
متن کاملIlluminating the glomerular filtration barrier, two photons at a time.
The mechanisms by which the kidney retains albumin and larger proteins in the circulation while excreting smaller solutes remain enigmatic despite intense investigation. Although the controversy largely plays out in academic journals, the problem is anything but academic, because the health of millions of adults hinges on effective treatment of proteinuric CKD. Proteinuria is associated with ca...
متن کامل“Zebrafishing” for Novel Genes Relevant to the Glomerular Filtration Barrier
Data for genes relevant to glomerular filtration barrier function or proteinuria is continually increasing in an era of microarrays, genome-wide association studies, and quantitative trait locus analysis. Researchers are limited by published literature searches to select the most relevant genes to investigate. High-throughput cell cultures and other in vitro systems ultimately need to demonstra...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2009
ISSN: 1062-4821
DOI: 10.1097/mnh.0b013e3283296044